Thionyl Chloride → 6,7-Dihydroxy-4-oxo-4H-1-benzopyran-3-carbonyl chloride

HRID 894982ノート

反応式

HRID 894982 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13](O)=[O:14])[C:5]2=[O:16].S(Cl)([Cl:19])=O>>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13]([Cl:19])=[O:14])[C:5]2=[O:16]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 122007766,7-Dihydroxychromon-3-carboxylic acid

生成物 1

HCID 127657576,7-Dihydroxy-4-oxo-4H-1-benzopyran-3-carbonyl chloride収率 93.4%

実験手順

A mixture of 6,7-dihydroxychromone-3-carboxylic acid (9.0 g, 4 mmol) and thionyl chloride (150 ml) was refluxed for 45 minutes and the thionyl chloride was evaporated. After the addition of benzene, the mixture was evaporated again to dryness and the residue was triturated with n-hexane to afford the desired compound (9.1 g, 93.4%).

後処理

  1. temperaturewas refluxed for 45 minutes
  2. customthe thionyl chloride was evaporated
  3. additionAfter the addition of benzene
  4. customthe mixture was evaporated again to dryness
  5. customthe residue was triturated with n-hexane

出典と根拠

ORDレコード
ord-116ccc2ab25c488290a07b55c7ee64d8
出典データセット
uspto-grants-1981_08
特許番号
US04285939

反応ノート

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