Acetone → Diethyl Isopropylidenesuccinate

HRID 895265ノート

反応式

HRID 895265 の反応式
[O-]CC.[K+].[C:5]([O:14][CH2:15][CH3:16])(=[O:13])[CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].[CH3:17][C:18]([CH3:20])=O.C(Br)C>CN(C)C=O>[C:18](=[C:6]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:5]([O:14][CH2:15][CH3:16])=[O:13])([CH3:20])[CH3:17]

参加物

6

反応物 4

HCID 180AcetoneHCID 6332Ethyl BromideHCID 31249Diethyl SuccinateHCID 23670592Potassium ethoxide

生成物 1

HCID 251287Diethyl Isopropylidenesuccinate収率 95%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

52.5 mmol of potassium ethoxide were suspended in 100 mL of N,N-dimethylformamide in a 250 mL round bottom flask. To this slurry, heated up to 60° C., a mixture of 50 mmol of diethyl succinate and 57.5 mmol of acetone was added dropwise in 10 minutes. The course of the reaction was detected by GC. After 60 minutes the reaction was completed with a conversion of 97.2% (determined by GC). Then 87.5 mmol of ethyl bromide were added to the reaction mixture at 60° C. The slurry was stirred for 60 minutes at 60° C. The reaction was complete, giving the product isomers with a yield of 95% (determined by GC).

後処理

  1. additionwas added dropwise in 10 minutes
  2. customgiving the product isomers with a yield of 95% (determined by GC)

出典と根拠

ORDレコード
ord-0d49c6bdef4a4219959a91e7c4568ee2
出典データセット
uspto-grants-2005_07
特許番号
US06914153B2

反応ノート

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