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Piperidine → N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 2-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide | HCID 22379151 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide | HCID 22353518 | — |
反応手順
2-Bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide (28 mg) was dissolved in acetonitrile (2 ml) and piperidine added (23 μl in 500 ul acetonitrile). The mixture was left to stir for 1.5 hr after which time the solvent was removed in vacuo. Purification using a short silica plug, eluting with a mixture of ethyl acetate and petroleum ether (1:1 v/v) furnished the title compound (25 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06916804B2 |
| 出典データセット | uspto-grants-2005_07 |
| ORD ID | ord-ad95920473d8498281b9e63a8038cdd2 |
| 出典メモ | uspto-grants-2005_07 |