Piperidine → N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide

HRID 895476Notes

Reaction equation

HRID 895476 reaction equation
Br[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[C:10]([Cl:12])[N:9]=[C:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:7]=1)=[O:4].[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C(#N)C>[Cl:12][C:10]1[N:9]=[C:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:11]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 223791512-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide

Product 1

HCID 22353518N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

2-Bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide (28 mg) was dissolved in acetonitrile (2 ml) and piperidine added (23 μl in 500 ul acetonitrile). The mixture was left to stir for 1.5 hr after which time the solvent was removed in vacuo. Purification using a short silica plug, eluting with a mixture of ethyl acetate and petroleum ether (1:1 v/v) furnished the title compound (25 mg).

Workup

  1. waitThe mixture was left
  2. customwas removed in vacuo
  3. customPurification
  4. washeluting with a mixture of ethyl acetate and petroleum ether (1:1 v/v)

Sources & evidence

ORD record
ord-ad95920473d8498281b9e63a8038cdd2
Source dataset
uspto-grants-2005_07
Patent number
US06916804B2

Reaction notes

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