Hydrochloric Acid → HCID 178516641、化合物

HRID 895488

反応式

HRID 895488 の反応式
[O-]CC.[Na+].[Cl:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([NH2:12])=[NH:11])=[CH:8][CH:7]=1.[C:15](OCC)(=[O:22])[CH2:16][C:17](OCC)=[O:18].Cl>C(O)C>[Cl:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]2[N:12]=[C:17]([OH:18])[CH:16]=[C:15]([OH:22])[N:11]=2)=[CH:8][CH:7]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 7761Diethyl MalonateHCID 2034374-ChlorobenzamidineHCID 2723922Sodium ethoxide

生成物 1

HCID 178516641HCID 178516641、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

反応条件

温度
40 °C

実験手順

To sodium ethoxide (48 ml of a 21% wt solution in ethanol diluted with a further 130 ml ethanol) was added 4-chlorobenzamidine (8 g) and diethyl malonate (6.67 ml) and the solution left to stir at 40° C. for 96 hrs. The reaction mixture was subsequently cooled to 5° C. and acidified cautiously to pH 2 using concentrated hydrochloric acid. The solid thus precipitated was filtered, washed with excess cold water, then 50 ml diethyl ether and dried in vacuo yielding the title compound (7.51 g).

後処理

  1. waitthe solution left
  2. temperatureThe reaction mixture was subsequently cooled to 5° C.
  3. customThe solid thus precipitated
  4. filtrationwas filtered
  5. washwashed with excess cold water
  6. dry with material50 ml diethyl ether and dried in vacuo

出典と根拠

ORDレコード
ord-7724f17f420741168f75f8b88270b3d2
出典データセット
uspto-grants-2005_07
特許番号
US06916804B2

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