Trifluoroacetic acid → 4-(2,6-Difluorophenyl)-4-oxobutyric acid
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9](=[O:19])[CH2:10][CH2:11][C:12]([O:14]C(C)(C)C)=[O:13].FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9](=[O:19])[CH2:10][CH2:11][C:12]([OH:14])=[O:13]参加物
4
実験手順
A solution of tert-Butyl 4-(2,6-difluorophenyl)-4-oxobutyrate (Step A, 9.52 g, 35.2 mmol) in dichloromethane (30 ml) was treated with trifluoroacetic acid (20 ml). The mixture was stirred at ambient temperature for 3 hours and concentrated. The purification was done by flash chromatography on silica gel column (chloroform:methanol, 95:5 spiked with acetic acid) to provide the title compound as a white solid.
後処理
- concentrationconcentrated
- customThe purification
出典と根拠
- ORDレコード
- ord-e8e60a1894b14c53bfa5d61535e803a2
- 出典データセット
- uspto-grants-2005_07
- 特許番号
- US06916848B2
反応ノート
読み込み中…