Sodium Hydroxide → 4-(3-(2,6-Dimethylbenzyloxy)phenyl)-4-oxo-2-butenoic acid
反応式
[CH3:1][C:2]1[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:20])[CH:13]=[CH:14][C:15]([O:17]CC)=[O:16])[CH:9]=[CH:10][CH:11]=1.[OH-].[Na+]>C(O)C>[CH3:25][C:21]1[CH:22]=[CH:23][CH:24]=[C:2]([CH3:1])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:20])[CH:13]=[CH:14][C:15]([OH:17])=[O:16])[CH:9]=[CH:10][CH:11]=1参加物
4
実験手順
To a solution of Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxo-2-butenoate (Step E) in abs ethanol at low temp, add aqueous sodium hydroxide, after an hour, concentrate and purify by flash chromatography on silica gel column (chloroform:methanol 95:5 spiked with acetic acid).
後処理
- waitafter an hour
- concentrationconcentrate
- custompurify by flash chromatography on silica gel column (chloroform:methanol 95:5 spiked with acetic acid)
出典と根拠
- ORDレコード
- ord-1b8b88d8de2b4a2da138d50bfb2d3be8
- 出典データセット
- uspto-grants-2005_07
- 特許番号
- US06916848B2
反応ノート
読み込み中…