Hydrochloric Acid → alpha,alpha-Dimethyl-2-naphthaleneethanamine
反応式
[CH3:1][C:2]([NH:15]C(=O)C)([CH3:14])[CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=1.Cl.[OH-].[Na+]>O>[CH3:14][C:2]([NH2:15])([CH3:1])[CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=1参加物
5
実験手順
To N-[2-methyl-1-(naphthalen-2-yl)propan-2-yl]acetamide (26 mg) obtained in Step 8 was added 6N hydrochloric acid (2 ml) and the mixture was heated under reflux for 5 hr. The reaction mixture was poured into water, made basic with a 4N aqueous sodium hydroxide solution, and extracted with diethyl ether. The organic layer was washed with water, dried over potassium carbonate and concentrated under reduced pressure to give the title compound (19 mg).
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 5 hr
- extractionextracted with diethyl ether
- washThe organic layer was washed with water
- dry with materialdried over potassium carbonate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-8d1a65d1e9f44f4cb61297243c0c3a2c
- 出典データセット
- uspto-grants-2005_07
- 特許番号
- US06916956B2
反応ノート
読み込み中…