Hydrochloric Acid → HCID 22349525、化合物

HRID 896073ノート

反応式

HRID 896073 の反応式
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[OH:11])=[CH:4][CH:3]=1.N1C(C)=CC=CC=1C.[CH:20]([Si:23](OS(C(F)(F)F)(=O)=O)([CH:27]([CH3:29])[CH3:28])[CH:24]([CH3:26])[CH3:25])([CH3:22])[CH3:21].Cl>C(Cl)Cl>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[O:11][Si:23]([CH:27]([CH3:29])[CH3:28])([CH:24]([CH3:26])[CH3:25])[CH:20]([CH3:22])[CH3:21])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 79372,6-LutidineHCID 2724529Triisopropylsilyl trifluoromethanesulfonateHCID 27548246-bromo-2,3-dihydro-1H-inden-1-ol

生成物 1

HCID 22349525HCID 22349525、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 6-Bromo-2,3-dihydro-1H-inden-1-ol (300 mg, 1.41 mmol) in CH2Cl2 (4 mL) was added 2,6-lutidine (151 μL, 1.41 mmol) followed by triisopropylsilyltriflate (378 μL, 1.41 mmol) at room temperature. The reaction was stirred for 30 min then added to 1N HCl and extracted. The organic layer was washed with saturated sodium bicarbonate then brine and dried over MgSO4. The solvent was removed in vacuo and the crude material purified by column chromatography.

後処理

  1. extractionextracted
  2. washThe organic layer was washed with saturated sodium bicarbonate
  3. dry with materialbrine and dried over MgSO4
  4. customThe solvent was removed in vacuo
  5. customthe crude material purified by column chromatography

出典と根拠

ORDレコード
ord-591e89d93cee4268ba645c7de5d02c94
出典データセット
uspto-grants-2005_07
特許番号
US06919335B2

反応ノート

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