Nitric Acid → 2(3H)-Benzothiazolone, 6-nitro-

HRID 896505ノート

反応式

HRID 896505 の反応式
[S:1]1(=O)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[N+:11]([O-])([OH:13])=[O:12].C(OC(=O)C)(=[O:17])C>>[N+:11]([C:7]1[CH:8]=[CH:9][C:4]2[NH:3][C:2](=[O:17])[S:1][C:5]=2[CH:6]=1)([O-:13])=[O:12]

参加物

4

反応物 3

HCID 944Nitric AcidHCID 7918Acetic AnhydrideHCID 53400715Benzothiazolinone

生成物 1

HCID 6415712(3H)-Benzothiazolone, 6-nitro-

反応条件

温度
-10 °C

実験手順

0.1 mol of benzothiazolinone is dissolved in 100 ml of acetic anhydride and the solution is cooled to −10° C. 10 ml of nitric acid are then added dropwise, and the reaction is stirred for 2 hours. The resulting precipitate is filtered off and washed with water, and then purified by chromatography (eluant CH2Cl2 then AcOEt) to yield the title product, which is recrystallised from ethanol.

後処理

  1. filtrationThe resulting precipitate is filtered off
  2. washwashed with water
  3. custompurified by chromatography (eluant CH2Cl2

出典と根拠

ORDレコード
ord-1fbddb1298af4da6a2867526236a7614
出典データセット
uspto-grants-2005_07
特許番号
US06919362B2

反応ノート

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