Thionyl Chloride → 8-{3-[Chloro-(4-chloro-phenyl)-methyl]-phenyl}-6-isopropyl-quinoline

HRID 896682ノート

反応式

HRID 896682 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH:17]=[C:18]([CH:26]([CH3:28])[CH3:27])[CH:19]=[C:20]4[C:25]=3[N:24]=[CH:23][CH:22]=[CH:21]4)[CH:11]=2)O)=[CH:4][CH:3]=1.O=S(Cl)[Cl:31]>C1C=CC=CC=1>[Cl:31][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[C:10]1[CH:11]=[C:12]([C:16]2[CH:17]=[C:18]([CH:26]([CH3:28])[CH3:27])[CH:19]=[C:20]3[C:25]=2[N:24]=[CH:23][CH:22]=[CH:21]3)[CH:13]=[CH:14][CH:15]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 22350111(4-Chloro-phenyl)-[3-(6-isopropyl-quinolin-8-yl)-phenyl]-methanol

生成物 1

HCID 223501108-{3-[Chloro-(4-chloro-phenyl)-methyl]-phenyl}-6-isopropyl-quinoline

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a solution of (4-chloro-phenyl)-[3-(6-isopropyl-quinolin-8-yl)-phenyl]-methanol from Step 1 (1.0 g, 2.58 mmol) in benzene (7 mL) at 0° C. was added SOCl2 (0.375 mL, 5.2 mmol) dropwise. After 45 min. at 0-10° C., the resulting reaction mixture was filtered through silica gel and celite and then concentrated.

後処理

  1. customthe resulting reaction mixture
  2. filtrationwas filtered through silica gel and celite
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-d447cc416d6a405e921c1340ad9667f7
出典データセット
uspto-grants-2005_07
特許番号
US06919353B2

反応ノート

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