Tetramethylammonium hydroxide → Lipoic acid

HRID 896940

反応式

HRID 896940 の反応式
[OH-].C[N+](C)(C)C.CC(C)([O-])C.[K+].[CH2:13]([CH2:19][C@@H:20]([SH:24])[CH2:21][CH2:22][SH:23])[CH2:14][CH2:15][C:16]([OH:18])=[O:17]>CN(C=O)C>[CH2:21]1[C@@H:20]([CH2:19][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[S:24][S:23][CH2:22]1.[CH2:13]([CH2:19][C@@H:20]([SH:24])[CH2:21][CH2:22][SH:23])[CH2:14][CH2:15][C:16]([OH:18])=[O:17]

参加物

6

反応物 3

HCID 60966Tetramethylammonium hydroxideHCID 9834298(R)-Dihydrolipoic acidHCID 23665647Potassium tert-butoxide

生成物 2

HCID 6112Lipoic acidHCID 9834298(R)-Dihydrolipoic acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In other synthetic schemes the base, tetramethylammonium hydroxide can be substituted for potassium t-butoxide in DMF. The former base though can be stored under air, whilst the latter needs to be kept in an inert atmosphere. The dihydrolipoic acid works best if it totally clear. If the reduction lipoic acid to produce dihydrolipoic acid is not complete, a yellow coloration of the solution will be evident. The yellow solution can be distilled (distills at 140° C. under vacuum) to yield a clear solution of dihydrolipoic acid.

出典と根拠

ORDレコード
ord-dfa8a8fbcaf8412da0e392ebd82dc423
出典データセット
uspto-grants-2005_07
特許番号
US06921496B2

関連ノート

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