Sodium Hydroxide → HCID 178488203、化合物

HRID 897956

反応式

HRID 897956 の反応式
C(O)(=O)/C=C\C(O)=O.C(O)(=O)/C=C\C(O)=O.[NH2:17][C:18]1[N:23]=[CH:22][N:21]=[C:20]2[N:24]([C@H:48]3[CH2:53][CH2:52][C@H:51]([N:54]4[CH2:59][CH2:58][N:57]([CH3:60])[CH2:56][CH2:55]4)[CH2:50][CH2:49]3)[N:25]=[C:26]([C:27]3[CH:32]=[CH:31][C:30]([NH:33][C:34]([C:36]4[N:37]([CH3:45])[C:38]5[C:43]([CH:44]=4)=[CH:42][CH:41]=[CH:40][CH:39]=5)=[O:35])=[C:29]([O:46][CH3:47])[CH:28]=3)[C:19]=12.[OH-].[Na+]>ClCCl>[NH2:17][C:18]1[N:23]=[CH:22][N:21]=[C:20]2[N:24]([C@H:48]3[CH2:49][CH2:50][C@H:51]([N:54]4[CH2:59][CH2:58][N:57]([CH3:60])[CH2:56][CH2:55]4)[CH2:52][CH2:53]3)[N:25]=[C:26]([C:27]3[CH:32]=[CH:31][C:30]([NH:33][C:34]([C:36]4[N:37]([CH3:45])[C:38]5[C:43]([CH:44]=4)=[CH:42][CH:41]=[CH:40][CH:39]=5)=[O:35])=[C:29]([O:46][CH3:47])[CH:28]=3)[C:19]=12

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 178488205HCID 178488205、化合物

生成物 1

HCID 178488203HCID 178488203、化合物収率 50.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A suspension of trans-N2-(4-{4-amino-1-[4-(4-methylpiperazino)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1H-2-indolecarboxamide di-maleate (0.200 g, 0.242 mmol) in dichloromethane (15 mL) was treated with 1N sodium hydroxide solution. The reaction mixture was stirred for 1 h at room temperature. The layers were partitioned using an Empore extraction cartridge. The organic layer was removed by blowing nitrogen over the top of the solvent to give 0.072 g (50%) of trans-N2-(4-{4-amino-1-[4-(4-methylpiperazino)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1H-2-indolecarboxamide.

後処理

  1. customThe layers were partitioned
  2. extractionan Empore extraction cartridge
  3. customThe organic layer was removed

出典と根拠

ORDレコード
ord-a34f1f3ea52343b999ab2bb1733db4e0
出典データセット
uspto-grants-2005_07
特許番号
US06921763B2

関連ノート

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