methyl 1H-indazole-3-carboxylate → HCID 10680335、化合物

HRID 898149ノート

反応式

HRID 898149 の反応式
[CH3:1][O:2][C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][N:6]=1)=[O:4].[CH3:14][C:15](C)([O-])[CH3:16].[K+]>O1CCCC1>[CH3:1][O:2][C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]([CH:15]([CH3:16])[CH3:14])[N:6]=1)=[O:4]

参加物

4

反応物 2

HCID 657476methyl 1H-indazole-3-carboxylateHCID 23665647Potassium tert-butoxide

生成物 1

HCID 10680335HCID 10680335、化合物収率 98.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of indazole-3-carboxylic acid methyl ester (40.7 g, 231 mmol) in anhydrous tetrahydrofuran (700 mL) cooled in an ice bath was added slowly solid potassium tert-butoxide (28.3 g, 252 mmol). The mixture was stirred at the same temperature for 1 hr prior to the addition of 2-iododopropane (34.4 mL, 367 mmol). The final mixture was stirred for 12 h at ambient temperature, and refluxed for 12 h. After cooling to room temperature, the mixture was filtered, and the collected solid was rinsed with tetrahydrofuran (100 mL). The filtrates were combined, and concentrated to dryness under reduced pressure, affording crude 1-isopropyl-1H-indazole-3-carboxylic acid methyl ester (49.7 g) as a pale yellow oil. The crude material was purified by flash silica gel chromatography eluting with hexane/ethyl acetate (9/1 to 3/1) to yield 1-isopropyl-1H-indazole-3-carboxylic acid methyl ester (43 g, 197 mmol, >99% pure). 1H-NMR (CD3OD, 300 MHz): δ (ppm) 8.1-8.0 (1H, d), 7.6 (1H, d), 7.4 (1H, t), 7.2 (1H, t), 5.0 (1H, quin), 3.9 (s, 3H), 1.5 (6H, d).

後処理

  1. additionto the addition of 2-iododopropane (34.4 mL, 367 mmol)
  2. temperaturerefluxed for 12 h
  3. filtrationthe mixture was filtered
  4. washthe collected solid was rinsed with tetrahydrofuran (100 mL)
  5. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-42fd78b7cda74563a8aa5c35cad9e8fe
出典データセット
uspto-grants-2008_04
特許番号
US07351704B2

反応ノート

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