Bromoacetyl bromide → 2-Bromo-n-[3-chloro-4-(2-diethylamino-ethoxy)-phenyl]-acetamide-hydrobromide
反応式
[Br:1][CH2:2][C:3](Br)=[O:4].[Cl:6][C:7]1[CH:8]=[C:9]([NH2:21])[CH:10]=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][N:16]([CH2:19][CH3:20])[CH2:17][CH3:18]>ClCCl>[BrH:1].[Br:1][CH2:2][C:3]([NH:21][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH2:14][CH2:15][N:16]([CH2:19][CH3:20])[CH2:17][CH3:18])=[C:7]([Cl:6])[CH:8]=1)=[O:4]参加物
4
実験手順
A solution of 1.86 mL (21.00 mmol) of bromoacetylbromide in 10 mL of dichloromethane was added dropwise to a solution of 5.00 g (21.00 mmol) of 3-chloro-4-(2-diethylamino-ethoxy)-phenylamine. in 100 mL of dichloromethane at 0° C. and the mixture was stirred for 20 minutes at 0° C. The precipitate formed was filtered off, washed with dichloromethane and MTBE and dried i. vac. at 40° C.