Sodium Hydroxide → 4-(Cyanomethyl)benzoic acid

HRID 898533ノート

反応式

HRID 898533 の反応式
[C:1]([CH2:3][C:4]1[CH:14]=[CH:13][C:7]([C:8]([O:10]CC)=[O:9])=[CH:6][CH:5]=1)#[N:2].[OH-].[Na+]>C(O)C>[C:1]([CH2:3][C:4]1[CH:14]=[CH:13][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)#[N:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 11989373ethyl 4-(cyanomethyl)benzoate

生成物 1

HCID 2708714-(Cyanomethyl)benzoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 10 g (53 mol) of ethyl 4-cyanomethyl-benzoate and 2.02 mL of a 1 M sodium hydroxide solution in 100 mL of ethanol is refluxed for one hour. Then the reaction solution is evaporated down and the residue is combined with ice water. Concentrated hydrochloric acid is added dropwise to the reaction solution until no more precipitate is formed. The precipitate is filtered off, washed twice with water and dried.

後処理

  1. customThen the reaction solution is evaporated down
  2. additionConcentrated hydrochloric acid is added dropwise to the reaction solution until no more precipitate
  3. customis formed
  4. filtrationThe precipitate is filtered off
  5. washwashed twice with water
  6. customdried

出典と根拠

ORDレコード
ord-c716151ff7ca41a4ae826ba559d40f79
出典データセット
uspto-grants-2008_04
特許番号
US07351719B2

反応ノート

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