[2-(2-Chloro-4-nitrophenyl)ethyl]diethylamine → 3-Chloro-4-(2-diethylaminoethyl)phenylamine

HRID 898552ノート

反応式

HRID 898552 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15].[H][H]>[Ni].C1COCC1>[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15]

参加物

5

反応物 2

HCID 68816908[2-(2-Chloro-4-nitrophenyl)ethyl]diethylamineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 596916173-Chloro-4-(2-diethylaminoethyl)phenylamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A suspension of 2.00 g (7.790 mmol) [2-(2-chloro-4-nitro-phenyl)-ethyl]-diethyl-amine and 0.80 g Raney nickel in THF was hydrogenated for 2.5 h at RT and 25 psi hydrogen pressure. The catalyst was filtered off and the filtrate evaporated down i. vac.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated down i

出典と根拠

ORDレコード
ord-53c17b045afb46c680947db18f8e2a89
出典データセット
uspto-grants-2008_04
特許番号
US07351719B2

反応ノート

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