(2,4-Dichlorophenoxy)acetyl chloride → 2-(2,4-Dichloro-phenoxy)-n-[4-(2-diethylamino-ethoxy)-3-methoxy-phenyl]-acetamide

HRID 898557

反応式

HRID 898557 の反応式
[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6](Cl)=[O:7].[CH2:14]([N:16]([CH2:29][CH3:30])[CH2:17][CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][C:21]=1[O:27][CH3:28])[CH3:15].C(N(C(C)C)C(C)C)C>ClCCl>[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([NH:26][C:23]1[CH:24]=[CH:25][C:20]([O:19][CH2:18][CH2:17][N:16]([CH2:29][CH3:30])[CH2:14][CH3:15])=[C:21]([O:27][CH3:28])[CH:22]=1)=[O:7]

参加物

5

反応物 3

HCID 69887(2,4-Dichlorophenoxy)acetyl chlorideHCID 81531DiisopropylethylamineHCID 224961344-(2-Diethylaminoethoxy)-3-methoxyphenylamine

生成物 1

HCID 129974422-(2,4-Dichloro-phenoxy)-n-[4-(2-diethylamino-ethoxy)-3-methoxy-phenyl]-acetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 70 mg (0.290 mmol) of (2,4-dichloro-phenoxy)-acetylchloride in 0.5 mL dichloromethane was added to a solution of 66 mg (0.278 mmol) of 4-(2-diethylamino-ethoxy)-3-methoxy-phenylamine (intermediate product Z6b) and 96 μL (0.56 mmol) of ethyl-diisopropylamine in 1.5 mL abs. dichloromethane and the mixture was stirred for 15 hours at RT. The reaction mixture was evaporated down i. vac. and the residue was purified by column chromatography (silica gel, dichloromethane/MeOH 9:1).

後処理

  1. customThe reaction mixture was evaporated down i
  2. customand the residue was purified by column chromatography (silica gel, dichloromethane/MeOH 9:1)

出典と根拠

ORDレコード
ord-5c6dc6a4ad93421fae363aea205c7220
出典データセット
uspto-grants-2008_04
特許番号
US07351719B2

関連ノート

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