Trifluoroacetic acid → HCID 59691653、化合物
反応式
[Cl:1][C:2]1[CH:26]=[C:25]([NH:27][C:28](=[O:42])[CH2:29][O:30][C:31]2[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][C:32]=2[Cl:41])[CH:24]=[CH:23][C:3]=1[O:4][CH2:5][CH2:6][N:7]([CH2:21][CH3:22])[CH:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:26]=[C:25]([NH:27][C:28](=[O:42])[CH2:29][O:30][C:31]2[CH:36]=[CH:35][C:34]([C:37]([F:38])([F:39])[F:40])=[CH:33][C:32]=2[Cl:41])[CH:24]=[CH:23][C:3]=1[O:4][CH2:5][CH2:6][N:7]([CH2:21][CH3:22])[CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1参加物
4
実験手順
0.180 g (0.284 mmol) of tert.butyl 4-[(2-{2-chloro-4-[2-(2-chloro-4-trifluoromethyl-phenoxy)-acetylamino]-phenoxy}-ethyl)-ethyl-amino]-piperidine-1-carboxylate (from Example 97) were dissolved in 5.0 mL dichloromethane. After the addition of 0.44 mL (5.680 mmol) of trifluoroacetic acid the mixture was stirred for 2 hours at RT. The reaction solution was evaporated down i. vac. and the residue combined with sat. aqueous sodium hydrogen carbonate solution. The aqueous phase was extracted with EtOAc. The org. phase was dried over magnesium sulphate, filtered and evaporated down i. vac. Further purification was carried out by column chromatography.