Perindopril Erbumine → Perindopril erbumine monohydrate

HRID 898743

反応式

HRID 898743 の反応式
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29]>C(OCC)(=O)C>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:6]

参加物

3

反応物 1

HCID 441313Perindopril Erbumine

生成物 1

HCID 9847044Perindopril erbumine monohydrate収率 163.3%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Perindopril erbumine (20 gms) was suspended in ethyl acetate (300 ml). The contents were heated to dissolve the solids and cooled to 10 EC. The resulting slurry was filtered and dried in air having a relative humidity of at least 75% to give perindopril erbumine monohydrate (17 gms).

後処理

  1. temperatureThe contents were heated
  2. dissolutionto dissolve the solids
  3. temperaturecooled to 10 EC
  4. filtrationThe resulting slurry was filtered
  5. customdried in air

出典と根拠

ORDレコード
ord-a699c9ecef724a7c98932c97321fce17
出典データセット
uspto-grants-2008_04
特許番号
US07351840B2

関連ノート

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