Tyrosol → Tert-butyl [4-(2-hydroxyethyl)phenoxy]acetate

HRID 898888

反応式

HRID 898888 の反応式
[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>C(#N)C>[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 10393TyrosolHCID 11430Potassium CarbonateHCID 79177tert-Butyl bromoacetate

生成物 1

HCID 23119602Tert-butyl [4-(2-hydroxyethyl)phenoxy]acetate収率 92.8%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 4-(2-hydroxyethyl)phenol (3.8 ml, 25.834 mmol) was dissolved in acetonitrile (25 ml), potassium carbonate (7.085 g, 51.267 mmol) and tert-butyl bromoacetate (5.000 g, 25.834 mmol) was boiled under reflux for 16 hours. The solvent was evaporated under reduced pressure. The residue was dissolved in EtOAc and washed with brine and water, dried with MgSO4 and evaporated under reduced pressure to give the desired product was obtained (6.00 g, yield 92.8%).

後処理

  1. temperatureunder reflux for 16 hours
  2. customThe solvent was evaporated under reduced pressure
  3. dissolutionThe residue was dissolved in EtOAc
  4. washwashed with brine and water
  5. dry with materialdried with MgSO4
  6. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-58f39174f9d74c3780ae4c7f363807aa
出典データセット
uspto-grants-2008_04
特許番号
US07351858B2

関連ノート

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