Trifluoroacetic acid → Methyl 5-amino-2-hydroxypentanoate

HRID 899049ノート

反応式

HRID 899049 の反応式
C(O)(C(F)(F)F)=O.[CH3:8][O:9][C:10](=[O:24])[CH:11]([OH:23])[CH2:12][CH2:13][CH2:14][NH:15]C(OC(C)(C)C)=O>C(Cl)Cl>[CH3:8][O:9][C:10](=[O:24])[CH:11]([OH:23])[CH2:12][CH2:13][CH2:14][NH2:15]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 543300255-Tert-butoxycarbonylamino-2-hydroxy-pentanoic acid methyl ester

生成物 1

HCID 54185808Methyl 5-amino-2-hydroxypentanoate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

TFA (2 mL) was added to a solution of 5-tert-butoxycarbonylamino-2-hydroxy-pentanoic acid methyl ester in methylene chloride (10 mL) and the mixture was stirred for 3 h and then concentrated under reduced pressure to give crude 5-amino-2-hydroxy-pentanoic acid methyl ester (1 g).

後処理

  1. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-1dba90dc5cb4467f92220c7b7478df83
出典データセット
uspto-grants-2008_04
特許番号
US07354895B1

反応ノート

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