Ethanolamine → 4-{2-[(2-Hydroxyethyl)amino]ethoxy}benzonitrile
反応式
Br[CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1.[CH2:13]([CH2:15][NH2:16])[OH:14]>>[OH:14][CH2:13][CH2:15][NH:16][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1参加物
3
反応条件
- 温度
- 120 °C
実験手順
4-(2-Bromoethoxy)benzonitrile (30 g, 0.133 mol; see step (i) above) and ethanolamine (48 mL, 0.78 mol) were mixed and refluxed, under a nitrogen atmosphere, at about 120° C. for 3 h. The reaction was quenched by addition of a sodium hydroxide solution to the mixture. The sub-title compound was extracted using DCM (2×250 mL), which was dried over anhydrous sodium sulfate and then concentrated. Yield: 13.1 g (48%).
後処理
- customThe reaction was quenched by addition of a sodium hydroxide solution to the mixture
- extractionThe sub-title compound was extracted
- dry with materialwas dried over anhydrous sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-00d4aad05e8c4e0792eb2acf6c3fe321
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07354917B2
反応ノート
読み込み中…