Hydrogen Bromide → 2,1,3-Benzothiadiazol-5-ol
反応式
C[O:2][C:3]1[CH:11]=[CH:10][C:6]2=[N:7][S:8][N:9]=[C:5]2[CH:4]=1.Br>>[N:7]1[S:8][N:9]=[C:5]2[CH:4]=[C:3]([OH:2])[CH:11]=[CH:10][C:6]=12参加物
3
反応条件
- 温度
- 10 °C
実験手順
5-Methoxy-benzo-[2,1,3]-thiadiazole (4.09 g, 24.6 mmol) was stirred with hydrobromic acid (60 ml, 165 mmol, 30% in acetic acid) at 80° C. for 5 days. The mixture was cooled to 10° C. and filtered. The solids were purified by short column chromatography (50% ethyl acetate/hexane). Solvents were stripped in vacuo to afford 1.0 g of a yellow solid (27% yield).
後処理
- filtrationfiltered
- customThe solids were purified by short column chromatography (50% ethyl acetate/hexane)
出典と根拠
- ORDレコード
- ord-93f18af351de42168a5a403522aaabb9
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07354941B2
反応ノート
読み込み中…