Hydrochloric Acid → 3,6,9,12,15,18,21-Heptaoxatricosanoic acid, 23,23,23-trifluoro-

HRID 899428ノート

反応式

HRID 899428 の反応式
[F:1][C:2]([F:30])([F:29])[CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH2:17][CH2:18][O:19][CH2:20][CH2:21][O:22][CH2:23][C:24]([O:26]CC)=[O:25].Cl>[OH-].[Na+].[Cl-].[Na+].O>[F:1][C:2]([F:29])([F:30])[CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH2:17][CH2:18][O:19][CH2:20][CH2:21][O:22][CH2:23][C:24]([OH:26])=[O:25]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 17956300HCID 17956300、化合物

生成物 1

HCID 102737623,6,9,12,15,18,21-Heptaoxatricosanoic acid, 23,23,23-trifluoro-収率 88%

試薬・触媒・溶媒 2

HCID 14798Sodium Hydroxide溶媒HCID 57417360Sodium chloride; water溶媒

実験手順

The product of step (e) (400 mg) was dissolved in an aqueous sodium hydroxide solution (0.1M) (10 ml) and the reaction was stirred at room temperature for 16 hours. The reaction mixture was acidified to pH 2 by the addition of hydrochloric acid (2M), then this was diluted with brine (200 ml) and extracted with dichloromethane (2×200 ml). The combined organic layers were dried and the solvent removed in vacuo to give the title compound as a colourless oil (330 mg).

後処理

  1. extractionextracted with dichloromethane (2×200 ml)
  2. customThe combined organic layers were dried
  3. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-6c11f587751e4f65be609191c3e9a1b3
出典データセット
uspto-grants-2008_04
特許番号
US07354966B2

反応ノート

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