Ethyl isocyanate → HCID 178465301、化合物

HRID 900019ノート

反応式

HRID 900019 の反応式
[C:1]1([C:7]2[CH:16]=[CH:15][C:10]3[NH:11][C:12]([NH2:14])=[N:13][C:9]=3[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:17]([N:19]=[C:20]=[O:21])[CH3:18]>C1COCC1>[CH2:17]([NH:19][C:20]([NH:14][C:12]1[NH:11][C:10]2[CH:15]=[CH:16][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:8][C:9]=2[N:13]=1)=[O:21])[CH3:18]

参加物

4

反応物 2

HCID 8022Ethyl isocyanateHCID 178508149HCID 178508149、化合物

生成物 1

HCID 178465301HCID 178465301、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 7 (40 mg, 0.19 mmol) in THF (1 mL) was added ethyl isocyanate (27 μL, 0.34 mmol) as a solution in THF (0.5 mL). The reaction was heated to reflux overnight then concentrated in vacuo. The crude product was purified by preparative HPLC to afford Ia-84.

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux overnight
  3. concentrationthen concentrated in vacuo
  4. customThe crude product was purified by preparative HPLC
  5. customto afford Ia-84

出典と根拠

ORDレコード
ord-4814260c24bf463692af965e4b648b6c
出典データセット
uspto-grants-2008_04
特許番号
USRE040245E1

反応ノート

読み込み中…