Piperidine → 2-[4-(1H-indol-3-ylmethylene)-5-oxo-1-phenyl-4,5-dihydro-2,3,6,10b-tetraaza-benzo[e]azulen-6-yl]-N-isopropyl-N-phenyl-acetamide

温度

110 °C

To a solution of N-isopropyl-2-(5-oxo-1-phenyl-4,5-dihydro-2,3,6,10b-tetraaza-benzo[e]azulen-6-yl)-N-phenyl-acetamide (Preparation 7(A)) (1.2 g, 2.7 mmol) and piperidine (0.4 mL, 1.33 mmol) in toluene was added 1H-indole-3-carbaldehyde (0.46 g, 3.2 mmol). The reaction mixture was heated at 110° C. for 31 hours. Activated 4 Å molecular sieves (2 g) were added. The reaction mixture was heated for 24 hours at 110° C. The reaction was cooled to room temperature and the molecular sieves were filtered with the aid of toluene. The filtrate was concentrated and the residue was purified by chromatography (12%-20% acetone/methylene chloride) to give 1.5 g of 2-[4-(1H-indol-3-ylmethylene)-5-oxo-1-phenyl-4,5-dihydro-2,3,6,10b-tetraaza-benzo[e]azulen-6-yl]-N-isopropyl-N-phenyl-acetamide as a solid. MS 579.2 (M+1).

1. additionActivated 4 Å molecular sieves (2 g) were added
2. temperatureThe reaction mixture was heated for 24 hours at 110° C
3. temperatureThe reaction was cooled to room temperature
4. filtrationthe molecular sieves were filtered with the aid of toluene
5. concentrationThe filtrate was concentrated
6. customthe residue was purified by chromatography (12%-20% acetone/methylene chloride)

ORDレコード

ord-eefe22a978014e24b6542e06ffe4eceb

出典データセット

uspto-grants-2008_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07358242B2