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Hydrochloric Acid → 3-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-3H-imidazole-4-carboxylic acid

HRID 900232
ノート
印刷プレビュー

反応式

HRID 900232 の反応式
C[O:2][C:3]([C:5]1[N:6]([CH2:10][C:11]2[CH:15]=[C:14]([C:16]3[S:17][C:18]([Cl:21])=[CH:19][CH:20]=3)[O:13][N:12]=2)[CH:7]=[N:8][CH:9]=1)=[O:4].O.[OH-].[Li+].Cl>C1COCC1.O>[Cl:21][C:18]1[S:17][C:16]([C:14]2[O:13][N:12]=[C:11]([CH2:10][N:6]3[C:5]([C:3]([OH:4])=[O:2])=[CH:9][N:8]=[CH:7]3)[CH:15]=2)=[CH:20][CH:19]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 691125593-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-3H-imidazole-4-carboxylic acid methyl ester

生成物 1

HCID 691130993-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-3H-imidazole-4-carboxylic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒
HCID 8028
Tetrahydrofuran
溶媒

反応条件

温度
60 °C

実験手順

To a solution of 720 mg 3-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-3H-imidazole-4-carboxylic acid methyl ester in 10 ml THF and 3 ml water, 57.0 mg lithium hydroxide monohydrate were added. After stirring for 2 h at 60° C. the reaction was cooled to RT. The mixture was acidified with half concentrated hydrochloric acid and the precipitate collected by filtration and washed with 3 ml water. The product was obtained as a white solid which was dried under reduced pressure. Yield: 650 mg

後処理

  1. temperaturewas cooled to RT
  2. filtrationthe precipitate collected by filtration
  3. washwashed with 3 ml water
  4. customThe product was obtained as a white solid which
  5. customwas dried under reduced pressure

出典と根拠

ORDレコード
ord-b4682ecc42c9478b82e8da74ffb67ad0
出典データセット
uspto-grants-2008_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07358268B2

反応ノート

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