Propylene Oxide → alpha-Methyl-2-furanethanol
反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.C([Li])CCC.[CH2:11]1[O:14][CH:12]1[CH3:13]>O1CCCC1>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:11][CH:12]([OH:14])[CH3:13]参加物
5
実験手順
To a solution of furan (7.93 g) in tetrahydrofuran (100 ml) cooled to 5° C. was added dropwise n-butyl lithium (80.2 ml, 1.6M in hexanes). The mixture was stirred for 2 h. A solution of propylene oxide (12.2 ml) was added dropwise and the resulting mixture was stirred at 0° C. for 1 h. The reaction mixture was quenched with saturated ammonium chloride and extracted with diethyl ether. The organics were dried (MgSO4) and concentrated. The crude oil was distilled to give 1-(2-furyl)-propan-2-ol (3.85 g, b.p. 68-70° C. at 6.0 mm).
後処理
- stirringthe resulting mixture was stirred at 0° C. for 1 h
- customThe reaction mixture was quenched with saturated ammonium chloride
- extractionextracted with diethyl ether
- dry with materialThe organics were dried (MgSO4)
- concentrationconcentrated
- distillationThe crude oil was distilled
出典と根拠
- ORDレコード
- ord-d72e89fe53f54547a35b54881864a80b
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07358376B2
反応ノート
読み込み中…