N-bromobutanimide → 2-Acetylamino-5-bromo-3-cyanothiophene
反応式
[C:1]([NH:4][C:5]1[S:6][CH:7]=[CH:8][C:9]=1[C:10]#[N:11])(=[O:3])[CH3:2].[Br:12]N1C(=O)CCC1=O>CN(C)C=O>[C:1]([NH:4][C:5]1[S:6][C:7]([Br:12])=[CH:8][C:9]=1[C:10]#[N:11])(=[O:3])[CH3:2]参加物
4
実験手順
2-Acetylamino-3-cyanothiophene (13.5 g) was dissolved in dimethylformamide (110 ml) and cooled in an ice/water bath. N-Bromosuccinimide (15.9 g) was added portion wise over 20 minutes and then the mixture warmed to room temperature and stirred for 3 h. The mixture was concentrated to approximately half the volume and water added to precipitate the product. This was filtered off and dried at 60° C. under vacuum (18.8 g).
後処理
- temperaturecooled in an ice/water bath
- concentrationThe mixture was concentrated to approximately half the volume and water
- additionadded
- customto precipitate the product
- filtrationThis was filtered off
- customdried at 60° C. under vacuum (18.8 g)
出典と根拠
- ORDレコード
- ord-f0baf2de5c144b1dbe1e459fa3ce055a
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07358376B2
反応ノート
読み込み中…