Dimethylformamide → HCID 86621080、化合物
反応式
C(Cl)(=O)C(Cl)=O.[Cl:7][C:8]1[N:9]=[C:10]([CH3:37])[N:11]([CH2:14][C:15]2[S:30][C:18]3[N:19]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:20](=[O:25])[N:21]([CH3:24])[C:22](=[O:23])[C:17]=3[C:16]=2[C:31]([N:33]([O:35]C)[CH3:34])=[O:32])[C:12]=1[Cl:13].CN(C)C=O>ClCCl>[Cl:7][C:8]1[N:9]=[C:10]([CH3:37])[N:11]([CH2:14][C:15]2[S:30][C:18]3[N:19]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:20](=[O:25])[N:21]([CH3:24])[C:22](=[O:23])[C:17]=3[C:16]=2[C:31]([N:33]([OH:35])[CH3:34])=[O:32])[C:12]=1[Cl:13]参加物
5
実験手順
Oxalyl chloride (0.1 62 ml) was added to a stirred solution of the product of example 1 part d) (415 mg) and dimethylformamide (0.01 ml) in dichloromethane (4 ml). After 1 h the solution was evaporated under reduced pressure. The residue was dissolved in anhydrous tetrahydrofuran (3 ml) and 1 ml of the solution was added to a stirred solution of N-methylhydroxylamine hydrochloride (129 mg) in saturated aqueous sodium bicarbonate solution (2 ml). After 1 h, the mixture was diluted with water (10 ml) and extracted with ethyl acetate (3×10 ml). Organic extracts were dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure to give the sub-title compound (129 mg).