反応式
[Li]CCCC.CCCCCC.[CH3:12][O:13][C@@:14]1([C:22]#[CH:23])[CH:19]2[CH2:20][CH2:21][N:16]([CH2:17][CH2:18]2)[CH2:15]1.[CH:24]1([C:31]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[O:32])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>C1COCC1>[CH:24]1([C:31]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)([OH:32])[C:23]#[C:22][C@:14]2([O:13][CH3:12])[CH:19]3[CH2:20][CH2:21][N:16]([CH2:17][CH2:18]3)[CH2:15]2)[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1参加物
反応条件
- 温度
- -5 °C
実験手順
A 1.6 N solution of BuLi in hexane (41.7 ml, 66.7 mmol) was added dropwise to a solution of (3R)-3-ethynyl-1-azabicyclo[2.2.2]oct-3-yl methyl ether 53 (11 g, 66.7 mmol) in THF (100 ml) cooled at −5° C. After stirring for 10 minutes, the medium was cooled at −15° C., and a solution of cycloheptyl(phenyl)methanone 44 (14.2 g, 70.2 mmol) in THF (50 ml) was slowly added. The cooling bath was removed and the reaction was allowed to gradually warm to room temperature during 2 hours. The reaction was quenched by the addition of saturated aqueous NH4Cl solution. The reaction mixture was washed with brine, dried over Na2SO4 and evaporated. The yellowish oil was purified by chromatography over silica gel (CH2Cl2/EtOH/NH4OH 94/6/1). 1-cycloheptyl-3-[(3R)-3-methoxy-1-azabicyclo[2.2.2]oct-3-yl]-1-phenyl-2-propyn-1-ol 116 was obtained as a white solid (20.35 g, 83%, mixture of diastereomers).
後処理
- temperaturethe medium was cooled at −15° C.
- customThe cooling bath was removed
- temperatureto gradually warm to room temperature during 2 hours
- customThe reaction was quenched by the addition of saturated aqueous NH4Cl solution
- washThe reaction mixture was washed with brine
- dry with materialdried over Na2SO4
- customevaporated
- customThe yellowish oil was purified by chromatography over silica gel (CH2Cl2/EtOH/NH4OH 94/6/1)
出典と根拠
- ORDレコード
- ord-0b5f7c8ca8064a15b6e47d696e40695f
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07361668B2
関連ノート
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