HCID 59699605、化合物 → HCID 59699556、化合物
反応式
COC1C=CC(C[N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][N:16]=3)[C:11]([Cl:18])=[C:10]([C:19]#[N:20])[C:9]2=[O:21])=CC=1>C(O)(C(F)(F)F)=O>[Cl:18][C:11]1[C:12]2[C:17](=[N:16][CH:15]=[CH:14][CH:13]=2)[NH:8][C:9](=[O:21])[C:10]=1[C:19]#[N:20]参加物
3
実験手順
A solution of 1-(4-methoxybenzyl)-4-chloro-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carbonitrile (32) (326 mg, 1 mmol) in TFA was refluxed for 24 h. The solution was cooled and excess TFA was distilled off under reduced pressure. The residue was taken in water, basified by solid NaHCO3 and filtered. The solids were washed with excess water and dried to yield 197 mg (95%) of 4-chloro-2-oxo-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile (31) as white solids. MP: 310° C.; 1H-NMR (DMSO-d6): δ 7.58 (dd, J=4.4, 8.0 Hz, 1H), 8.50 (d, J=2.0, 8.0 Hz, 1H), 8.83 (dd, J=4.4, 1.6 Hz, 1H), 13.03 (s, 1H); EIMS: 206 (M+1).
後処理
- temperatureThe solution was cooled