Diethylamine → 5-Bromo-2-diethylamino-nicotinic acid

HRID 901565ノート

反応式

HRID 901565 の反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5](F)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH2:12]([NH:14][CH2:15][CH3:16])[CH3:13]>C(#N)C>[Br:1][C:2]1[CH:3]=[N:4][C:5]([N:14]([CH2:15][CH3:16])[CH2:12][CH3:13])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 247213715-Bromo-2-fluoropyridine-3-carboxylic acid

生成物 1

HCID 597000725-Bromo-2-diethylamino-nicotinic acid

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
80 °C

実験手順

880 mg (4.00 mmol) of 5-bromo-2-fluoronicotinic acid was dissolved in 3 ml of acetonitrile. 1.0 ml (9.7 mmol) of diethylamine was added and the resulting mixture heated to 80° C. for 18 h. The mixture was evaporated and the resulting brown oil used without further purification. MS: m/z 273 [MH+].

後処理

  1. customThe mixture was evaporated
  2. customthe resulting brown oil used without further purification

出典と根拠

ORDレコード
ord-4300477f633b44e79f95f675e4576136
出典データセット
uspto-grants-2008_04
特許番号
US07361764B2

反応ノート

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