4-(Dibenzofuran-2-yloxy)-1-nitrobenzene → 4-(Dibenzofuran-2-yloxy)aniline

HRID 901709ノート

反応式

HRID 901709 の反応式
[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=1>CCOC(C)=O.[Pd]>[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1

参加物

4

反応物 1

HCID 21028934-(Dibenzofuran-2-yloxy)-1-nitrobenzene

生成物 1

HCID 669774564-(Dibenzofuran-2-yloxy)aniline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

The nitro intermediate (10 mmol) obtained above was dissolved in EtOAc (50 mL) and hydrogenated in the presence of 10% Pd/C (360 mg) until completion according to General Procedure H, as indicated by TLC or HPLC. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(dibenzofuran-2-yloxy)aniline, which was used directly for further transformation without further purification.

後処理

  1. filtrationThe reaction mixture was then filtered
  2. customto remove the catalyst
  3. customThe solvent was removed in vacuuo

出典と根拠

ORDレコード
ord-91c3553133314f1daa44a78be95675db
出典データセット
uspto-grants-2008_04
特許番号
US07361678B2

反応ノート

読み込み中…