Sodium Carbonate → Ethyl 4-nitro-L-phenylalanine
反応式
Cl.[CH2:2]([O:4][C:5](=[O:18])[C@H:6]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)[NH2:7])[CH3:3].C([O-])([O-])=O.[Na+].[Na+]>C(OCC)(=O)C>[CH2:2]([O:4][C:5](=[O:18])[C@H:6]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)[NH2:7])[CH3:3]参加物
4
実験手順
4-nitrophenylalanine ethyl ester hydrochloride (2 g, 1.0 eq, 7.28 mmol) obtained in step (i) was dissolved in ethyl acetate (150 mL). To that Na2CO3 (386 mg, 0.5 eq, 3.64 mmol) was added and was stirred for 15 min. The reaction mixture was washed with aq. NaHCO3. The organic layer was dried (Na2SO4), and condensed to obtain 4-nitrophenylalanine ethyl ester as thick oil (1.55 g, 89%).
後処理
- washThe reaction mixture was washed with aq. NaHCO3
- customThe organic layer was dried
- custom(Na2SO4), and condensed
出典と根拠
- ORDレコード
- ord-6d9d778bacb445ec9896a92e01a018b3
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07365064B2
反応ノート
読み込み中…