Chloroform → N-(1,2,3,4-tetrahydroquinolin-3-yl)acetamide
反応式
[C:1]([NH:4][C:5]1[CH:6]=[N:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)(=[O:3])[CH3:2].C(Cl)(Cl)Cl>C(O)(=O)C>[C:1]([NH:4][CH:5]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH2:6]1)(=[O:3])[CH3:2]参加物
4
実験手順
Borane-pyridine complex (320 mg, 3.5 mmol) was added to a solution of 3-acetamidoquinoline (320 mg, 1.7 mmol) in acetic acid (20 ml) and the mixture was stirred at room temperature for 18 h. Chloroform (150 ml) was added and the mixture was washed with 2N sodium hydroxide solution, water and brine. The organic phase was dried and reduced. Chromatography (80% EtOAc/20% 60-80 pet. ether) afforded 3-acetamido-1,2,3,4-tetrahydroquinoline (180 mg, 55%) as a pale yellow solid.
後処理
- washthe mixture was washed with 2N sodium hydroxide solution, water and brine
- customThe organic phase was dried
出典と根拠
- ORDレコード
- ord-9ad550024e81472dbea69b2c7a2f0b65
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07365065B2
反応ノート
読み込み中…