Water → Cbz-D-prolinol

HRID 901971ノート

反応式

HRID 901971 の反応式
[NH:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[CH2:6][OH:7].O.C(=O)([O-])O.[Na+].Cl[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16]>C(OCC)(=O)C>[OH:7][CH2:6][C@H:2]1[CH2:3][CH2:4][CH2:5][N:1]1[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16]

参加物

6

反応物 4

HCID 962WaterHCID 10387Benzyl chloroformateHCID 516892Sodium BicarbonateHCID 2724541Prolinol, (R)-

生成物 1

HCID 5314177Cbz-D-prolinol

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

2 g (0.0198 mol) of (2R)-pyrrolidin-2-ylmethanol was dissolved in 20 mL of ethyl acetate, 20 mL of water was added thereto, and the mixture was stirred. 3.3 g (0.30 mol) of sodium hydrogencarbonate was added to the mixture, followed by stirring of the mixture for 5 minutes. 4.24 mL (0.03 mol) of benzyl chloroformate was added dropwise to the mixture, followed by stirring for 5 hours. After the ethyl acetate layer was dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to quantitatively obtain the title compound.

後処理

  1. stirringby stirring of the mixture for 5 minutes
  2. stirringby stirring for 5 hours
  3. dry with materialAfter the ethyl acetate layer was dried over anhydrous sodium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-75db90d82a3f47dc8b976ee7874f1654
出典データセット
uspto-grants-2008_04
特許番号
US07365067B2

反応ノート

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