Ethyl formate → 5-Hydroxypentylformamide

HRID 901972

反応式

HRID 901972 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][OH:7].[CH:8](OCC)=[O:9]>>[OH:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:1][CH:8]=[O:9]

参加物

3

反応物 2

HCID 8025Ethyl formateHCID 756345-Aminopentan-1-ol

生成物 1

HCID 197823005-Hydroxypentylformamide収率 73%

反応条件

温度
90 °C

実験手順

2.06 g (20.0 mmol) of 5-amino-1-pentanol was dissolved in 5 mL of ethyl formate and the mixture was stirred at 90° C. for 4 hours. The solvent was distilled off under reduced pressure and the obtained residue was purified by silica gel chromatography (eluting solvent: ethyl acetate/methanol=100/0-70/30) to obtain 1.90 g (yield: 73%) of the title compound as a pale yellow-oil.

後処理

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe obtained residue was purified by silica gel chromatography (eluting solvent: ethyl acetate/methanol=100/0-70/30)

出典と根拠

ORDレコード
ord-bdeeaed94c8542f988f218988becbf56
出典データセット
uspto-grants-2008_04
特許番号
US07365067B2

関連ノート

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