化工社化工社 化学情報印刷レポート · 研究参考用
Gamma-Butyrolactone → Pyrrolidinone, (4-aminophenyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Gamma-Butyrolactone | HCID 7302 | — |
| 反応物 | P-Phenylenediamine | HCID 7814 | — |
| 溶媒 | Sodium Bicarbonate | HCID 516892 | — |
| 生成物 | Pyrrolidinone, (4-aminophenyl)- | HCID 676146 | — |
反応手順
800 mg Benzene-1,4-diamine and 600 μl Dihydro-furan-2-one were heated for 1 h to 200° C. under microwave irradiation (200 W, CEM Discover™ apparatus). Finally, 10 mL saturated NaHCO3 solution were added and the mixture was directly purified by chromatography on silica gel eluting with a gradient of DCM/MeOH 100%->50%. The fractions containing the product were combined and the solvent evaporated under reduced pressure. Yield: 860 mg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07365088B2 |
| 出典データセット | uspto-grants-2008_04 |
| ORD ID | ord-4327214eb5274d1ea3ad9d089429ea25 |
| 出典メモ | uspto-grants-2008_04 |