反应详情

800 mg Benzene-1,4-diamine and 600 μl Dihydro-furan-2-one were heated for 1 h to 200° C. under microwave irradiation (200 W, CEM Discover™ apparatus). Finally, 10 mL saturated NaHCO3 solution were added and the mixture was directly purified by chromatography on silica gel eluting with a gradient of DCM/MeOH 100%->50%. The fractions containing the product were combined and the solvent evaporated under reduced pressure. Yield: 860 mg.

1. customthe mixture was directly purified by chromatography on silica gel eluting with a gradient of DCM/MeOH 100%->50%
2. additionThe fractions containing the product
3. customthe solvent evaporated under reduced pressure