Mesitylene → HCID 69117214、化合物

HRID 902382ノート

反応式

HRID 902382 の反応式
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=1[Cl:19])C=C.[C:20]1(C)[CH:25]=C(C)C=C(C)[CH:21]=1>>[CH2:25]([C:10]1[CH:9]=[CH:8][C:7]([F:11])=[C:6]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=2[Cl:19])[C:5]=1[OH:4])[CH:20]=[CH2:21]

参加物

3

反応物 2

HCID 7947MesityleneHCID 691171992'-Allyloxy-2,4-dichloro-6'-fluorobiphenyl

生成物 1

HCID 69117214HCID 69117214、化合物収率 65%

実験手順

A solution of 2′-allyloxy-2,4-dichloro-6′-fluorobiphenyl (1.7 g, 5.7 mmol) in mesitylene (50 mL) was refluxed for 48 h. The solvent was removed under reduced pressure. Purification by ISCO using a solvent gradient of 0 to 20% ethyl acetate in hexanes provided 1.1 g (65%) of 3-allyl-2′,4′-dichloro-6-fluorobiphenyl-2-ol as a pale yellow oil.

後処理

  1. customThe solvent was removed under reduced pressure
  2. customPurification by ISCO

出典と根拠

ORDレコード
ord-a484fc6f7c3542d7b1ccaac581aa49dc
出典データセット
uspto-grants-2008_04
特許番号
US07365095B2

反応ノート

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