Pyridine → 3-Bromo-6-quinolinecarbonitrile

HRID 902569ノート

反応式

HRID 902569 の反応式
[Br:1]Br.N1C=CC=CC=1.[C:9]([C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]=[CH:16][CH:15]=[CH:14]2)#[N:10]>C(Cl)(Cl)(Cl)Cl>[Br:1][C:15]1[CH:16]=[N:17][C:18]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:9]#[N:10])=[CH:20][CH:19]=2

参加物

5

反応物 3

HCID 1049PyridineHCID 24408BromineHCID 592995Quinoline-6-carbonitrile

生成物 1

HCID 181862093-Bromo-6-quinolinecarbonitrile

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

In an amount of 37.8 mg of 6-cyanoquinoline (Justus Liebigs Ann. Chem., 1966, 699, 98-106) was dissolved in 1 ml of carbon tetrachloride, added with 13 μl of bromine, and then stirred under reflux. After 2 hours, the reaction mixture was added with 20 μl of pyridine, and further stirred for 23 hours under reflux. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate (4:1)) to obtain 34.8 mg of the title compound.

後処理

  1. temperatureunder reflux
  2. stirringfurther stirred for 23 hours
  3. temperatureunder reflux
  4. concentrationThe reaction mixture was concentrated under reduced pressure
  5. customthe resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate (4:1))

出典と根拠

ORDレコード
ord-f178da4f9adc49b598327e4d0468bb40
出典データセット
uspto-grants-2008_04
特許番号
US07365174B2

反応ノート

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