4-Toluenesulfonyl chloride → (3-[4-(Toluene-4-sulfonyloxy)butyl]phenyl}acetic acid methyl ester

HRID 902623ノート

反応式

HRID 902623 の反応式
[CH3:1][O:2][C:3](=[O:16])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][CH2:13][CH2:14][OH:15])[CH:6]=1.[C:17]1([CH3:27])[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1>N1C=CC=CC=1.O>[CH3:1][O:2][C:3](=[O:16])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][S:23]([C:20]2[CH:21]=[CH:22][C:17]([CH3:27])=[CH:18][CH:19]=2)(=[O:25])=[O:24])[CH:6]=1

参加物

5

反応物 2

HCID 73974-Toluenesulfonyl chlorideHCID 59745064{3-[4-Hydroxybutyl]phenyl)acetic acid methyl ester

生成物 1

HCID 86598282(3-[4-(Toluene-4-sulfonyloxy)butyl]phenyl}acetic acid methyl ester収率 63.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1049Pyridine溶媒

実験手順

A solution of {3-[4-hydroxybutyl]phenyl)acetic acid methyl ester (300 mg, 1.35 mmol) and p-toluenesulfonyl chloride (513 mg, 2.7 mmol) in pyridine (5 ml) was stirred at RT for 18 hr. The reaction was diluted with water (50 ml) and extracted with diethyl ether. The organic extracts were washed with water and cold 1N HCl, dried, and the solvent evaporated to give the title compound as an oil (322 mg, 63%). MS (ESI) 377.3 (M+H)+.

後処理

  1. extractionextracted with diethyl ether
  2. washThe organic extracts were washed with water and cold 1N HCl
  3. customdried
  4. customthe solvent evaporated

出典と根拠

ORDレコード
ord-ce9dc71d2f20480da1aa9df1808db461
出典データセット
uspto-grants-2008_04
特許番号
US07365085B2

反応ノート

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