4-Toluenesulfonyl chloride → 3-Chloropropyl p-toluenesulfonate

HRID 902720

反応式

HRID 902720 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][OH:5].[S:6](Cl)([C:9]1[CH:15]=[CH:14][C:12]([CH3:13])=[CH:11][CH:10]=1)(=[O:8])=[O:7]>N1C=CC=CC=1.O>[S:6]([O:5][CH2:4][CH2:3][CH2:2][Cl:1])([C:9]1[CH:15]=[CH:14][C:12]([CH3:13])=[CH:11][CH:10]=1)(=[O:8])=[O:7]

参加物

5

反応物 2

HCID 73974-Toluenesulfonyl chlorideHCID 123133-Chloro-1-propanol

生成物 1

HCID 694343-Chloropropyl p-toluenesulfonate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1049Pyridine溶媒

実験手順

A solution of 3-chloro-1-propanol (1.88 g, 20 mmole) in 20 ml of pyridine was treated at 0° with tosyl chloride (7.6 g, 40 mmole). The solution was warmed to 23°, and stirred 16 hours. The reaction was diluted with 100 mL of H2O and stirred for 90 minutes, and extracted with Et2O. The extracts were washed with 1N HCl, dried, and the solvents thoroughly removed, and gave the titled product, 2.3 g (46%). MS (ESI) 188 (MH+).

後処理

  1. temperatureThe solution was warmed to 23°
  2. stirringstirred for 90 minutes
  3. extractionextracted with Et2O
  4. washThe extracts were washed with 1N HCl
  5. customdried
  6. customthe solvents thoroughly removed

出典と根拠

ORDレコード
ord-2e0a2bb4065b47a0ace90b4fc7edbe3c
出典データセット
uspto-grants-2008_04
特許番号
US07365085B2

関連ノート

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