Benzylamine → (3R,4R)-1-benzyl-3,4-dihydroxypyrrolidine-2,5-dione
反応式
[C:1]([OH:10])(=O)[C@@H:2]([C@H:4]([C:6](O)=[O:7])[OH:5])[OH:3].[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C(C)=CC=CC=1>[CH2:11]([N:18]1[C:6](=[O:7])[C@H:4]([OH:5])[C@@H:2]([OH:3])[C:1]1=[O:10])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1参加物
4
反応条件
- 温度
- 150 °C
実験手順
L-Tartaric acid (30 g) and benzylamine (22 ml) were added to xylene (150 ml), and the mixture was heated under reflux at 150° C. for 3 hours using a Dean-Stark trap. After the reaction mixture was allowed to cool overnight, crystals were collected by filtration and washed with acetone. The resultant crude product was recrystallized from ethanol to obtain the title compound (23.2 g).
後処理
- temperaturethe mixture was heated
- temperatureto cool overnight
- filtrationcrystals were collected by filtration
- washwashed with acetone
- customThe resultant crude product was recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-b92a67768b5145719dccda173d76038a
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07365205B2
反応ノート
読み込み中…