4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane → 4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane

HRID 903196

反応式

HRID 903196 の反応式
[CH3:1][C:2]1([CH3:9])[O:6][CH:5]([CH2:7]Cl)[CH2:4][O:3]1.[N-:10]=[N+:11]=[N-:12].[Na+]>CN(C=O)C>[CH3:1][C:2]1([CH3:9])[O:6][CH:5]([CH2:7][N:10]=[N+:11]=[N-:12])[CH2:4][O:3]1

参加物

4

反応物 2

HCID 203744-(Chloromethyl)-2,2-dimethyl-1,3-dioxolaneHCID 33557Sodium Azide

生成物 1

HCID 115356024-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

15.05 g. of 2,2-dimethyl-4-chloromethyl-1,3-dioxolane is dissolved in 100 ml. DMF and 6.5 g. of NaN3 are added. The mixture is stirred at 50° overnight, cooled to room temperature, diluted with 300 ml. C6H6 and washed 5 times with water. The organic phase is dried and evaporated under reduced pressure to give 2,2-dimethyl-4-azidomethyl-1,3-dioxolane.

後処理

  1. additiondiluted with 300 ml
  2. washC6H6 and washed 5 times with water
  3. customThe organic phase is dried
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-cec873b6dcb746b281cfd8740518e9f1
出典データセット
uspto-grants-1980_10
特許番号
US04226866

関連ノート

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