Chloride → 4-Chlorophenyl 4-(8-cyclohexyloctylamino)benzoate

HRID 903412ノート

反応式

HRID 903412 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(N(CC)CC)C.[Cl-].Cl.[CH:18]1([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:33]2[CH:41]=[CH:40][C:36]([C:37](Cl)=[O:38])=[CH:35][CH:34]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>C(Cl)Cl>[CH:18]1([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:33]2[CH:41]=[CH:40][C:36]([C:37]([O:8][C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)=[O:38])=[CH:35][CH:34]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

参加物

6

反応物 4

HCID 312ChlorideHCID 46844-ChlorophenolHCID 8471TriethylamineHCID 20475769p-(8-Cyclohexyloctyl)aminobenzoyl chloride hydrochloride

生成物 1

HCID 204758364-Chlorophenyl 4-(8-cyclohexyloctylamino)benzoate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 6.4 g. 4-chlorophenol and 7.6 g. triethylamine in 500 ml. meythlene chloride is added 10.4 g. 4-(8-cyclohexyloctylamino)benzoyl chloride hydrochloride in 250 ml. methylene chloride. After four hours at reflux, the solution is cooled, washed with water and dilute phosphoric acid, and dried. After passing the solution through a column of alumina, the solvent is evaporated an the residue is crystallized from diisopropyl ether.

後処理

  1. temperatureAfter four hours at reflux
  2. temperaturethe solution is cooled
  3. washwashed with water and dilute phosphoric acid
  4. customdried
  5. customthe solvent is evaporated an the residue
  6. customis crystallized from diisopropyl ether

出典と根拠

ORDレコード
ord-3940520d066b43778c8bea81293339ff
出典データセット
uspto-grants-1980_10
特許番号
US04227014

反応ノート

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