Sodium Hydroxide → N-[4-(8-cyclohexyloctylamino)benzoyl]glycine

HRID 903419ノート

反応式

HRID 903419 の反応式
[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:30]=[CH:29][C:19]([C:20]([NH:22][CH2:23][C:24]([O:26]CC)=[O:25])=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:30]=[CH:29][C:19]([C:20]([NH:22][CH2:23][C:24]([OH:26])=[O:25])=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 20475823Ethyl 4-(8-cyclohexyloctylamino)hippurate

生成物 1

HCID 20475803N-[4-(8-cyclohexyloctylamino)benzoyl]glycine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 26.4 g. of ethyl N-[4-(8-cyclohexyloctylamino)benzoyl]glycinate, 110 ml. of 1 N sodium hydroxide solution; and 100 ml. of ethanol is stirred at ambient temperature for 2 hours and then partially evaporated. The aqueous solution is washed with diethyl ether, acidified with 6 N hydrochloric acid, and filtered. The white solid is dried in vacuo and recrystallized from acetone to yield the product.

後処理

  1. additionA mixture of 26.4 g
  2. custompartially evaporated
  3. washThe aqueous solution is washed with diethyl ether
  4. filtrationfiltered
  5. customThe white solid is dried in vacuo
  6. customrecrystallized from acetone
  7. customto yield the product

出典と根拠

ORDレコード
ord-aabe78f552ce425bb304f78cd88e5380
出典データセット
uspto-grants-1980_10
特許番号
US04227014

反応ノート

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