Water → 2-(azepan-4-yl)ethanol

HRID 903866ノート

反応式

HRID 903866 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([CH2:12][CH:13]1[CH2:20][CH2:19][CH2:18][NH:17][C:15](=O)[CH2:14]1)(OCC)=[O:8].O>O1CCCC1>[OH:8][CH2:7][CH2:12][CH:13]1[CH2:20][CH2:19][CH2:18][NH:17][CH2:15][CH2:14]1

参加物

5

反応物 3

HCID 962WaterHCID 20528706HCID 20528706、化合物HCID 21226445Aluminium lithium hydride

生成物 1

HCID 205287192-(azepan-4-yl)ethanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a stirred slurry of lithium aluminium hydride (5.70 g) in dry tetrahydrofuran (100 ml) was added β-carbethoxymethyl-caprolactam (10.3 g) in dry tetrahydrofuran (150 ml) over a period of 30 minutes. The mixture was refluxed for 2.5 hours, cooled and treated very slowly with water. The precipitate was filtered off and the filtrate was evaporated to yield the title compound as a viscous oil, which was used in the next step without purification.

後処理

  1. temperatureThe mixture was refluxed for 2.5 hours
  2. temperaturecooled
  3. filtrationThe precipitate was filtered off
  4. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-1937b8dea38e40008edd64b21d53b947
出典データセット
uspto-grants-1980_10
特許番号
US04229443

反応ノート

読み込み中…